What are the long-term effects of ingesting fluoride Alhava EM, Olkkonen H, Kauranen P, Kari T, The effect of drinking water fluoridation on the fluoride content, strength and mineral density of human ta Orthop Scand, 1980 June, 51 (3 413-420. The effect of drinking water fluoridation on the fluoride content of human bone, on cancellous bone strength and on the mineral density of bone was studied by analysing 158 autopsy. Port Manteaux churns out silly new words when you feed it an idea or two. Enter a word (or two) above and you'll get back a bunch of portmanteaux created by jamming together words that are conceptually related to your inputs. Port Manteaux Word Maker - OneLook Redtube Deutsch das geilere Redtube - Kostenlose Pornos For example, enter giraffe and you'll get. Lillia: Have you got any? Zantac 75 mg The suit, which lawyers said was filed late on Monday in the US District Court in Washington, DC, is the latest salvo in a long-running campaign by the heirs for return of the so-called Welfenschatz, or Guelph Treasure - which they claim.
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Jama, 1995 Mar 8, 273:10, 775-6.We report results of a population-based study of the relationship between concentrations of fluorine and calcium in drinking water and risk of hip fractures or fractures at any site. The risk of hip fractures was significantly higher when water fluorine concentration was higher than.11 mg/L (P.04 and this result persisted when using a mixed-effect logistic regression for taking into account the grouping of the subjects in parishes. Bone mass was lower in older women from the high fluoride community though not statistically so; these women reported significantly more fractures. Fluoride treatment increased bone fluoride levels 7-8 fold and reduced all biomechanical parameters. Young adult rabbits were treated with either 0 or 100 parts per million of fluoride in their drinking water for six months. A fluoride concentration of 50 ppm reduced femoral bone strength by 11 in control rats and by 31 in renal-deficient rats. Using engineering analyses of bone trabeculae, we calculate the losses in trabecular strength which can be caused by the presence of hypomineralized or hypermineralized fluorotic tissue. Bone mineral density (BMD) was measured at the spine and hip using dual energy X-ray absorptiometry and at the midpoint and ultradistal radius and calcaneus using single photon absorptiometry.
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The various pharmacokinetic parameters measured were not related to changes in LS BMD; however, there was an inverse relationship between trough fluoride concentration during long-term dosing and change in FN BMD. The fracture incidence showed an exponential increase with aging in men and women with an incidence about.5 times higher for women. Odds Ratio (OR) and 95 Confidence Interval (CI) for the Effect of Fluorine and Calcium Concentrations in Drinking Water on Risk of Hip Fractures Adjusted for Age, Sex, and Quetelet Index, and on Risk of Any Fractures Adjusted for Age and Sex Back to text. The relationship observed at the county level needs to be duplicated at the individual level with more precise measures of fluoride exposure. The effects of F Al on TyrP and cell proliferation were markedly reduced by 100 microM tyrphostin-51, a tyrosine kinase inhibitor. The number of new vertebral fractures was similar in the treatment and placebo groups (163 and 136, respectively; P not significant but the number of nonvertebral fractures was higher in the treatment group (72. Emphasis added Riggs BL, O'Fallon WM, Lane A, Hodgson SF, Wahner HW, Muhs J, Chao E, Melton LJ 3rd, Clinical trial of fluoride therapy in postmenopausal osteoporotic women: extended observations and additional analysis, J Bone Miner Res, 1994 Feb, 9:2, 265-275 excerpt from the paper. In bone mineral, this ion has been shown to affect bone crystal structure by increasing crystallinity and reducing specific surface area.
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Maylin GA, Eckerlin RH, Krook L, Fluoride intoxication in dairy calves, Cornell Vet, 1987 Jan, 77:1, 84-98 Chronic fluoride intoxication in dairy cattle, caused by feeding fluoride contaminated commercial feed, was previously described in a dairy herd. Spontaneous femoral neck or shaft fractures did not occur in either Groups 3. Case subjects were fetal growth chart chemnitz
all individuals aged 45 years or older residing in Edmonton or Calgary who were admitted to hospitals in Alberta between January 1, 1981, and December 31, 1987, and who had a discharge diagnosis of hip fracture. The incidence of hip fracture is also increasing more rapidly than can be accounted for by aging of the population. When the latter reached greater than 500 micrograms/g, pathological changes occurred in 90 of the bone. All of the women were participants in the Study of Osteoporotic Fractures. The tetracycline-covered bone surface returned to normal in the third biopsy. Its mineral structure is identical to that of heavy fluorosis and is characterized by the presence of additional large crystals, presumably located outside the collagen fibrils. By partial correlation, only the correlation between hip fractures/patient and bone fluoride remained significant after controlling for the effect of age (p less than.05). Mean fluoride and calcium of community drinking waters were 4 mg/L and 16 mg/L, respectively, high fluoride community; 1 mg/L and 375 mg/L, respectively, high calcium community; and 1 mg/L and 65 mg/L, respectively, low calcium community. Lee JR, Slow-Release Sodium Fluoride In The Management Of Postmenopausal Osteoporosis, Fluoride 1994 October, 27: (critical review - CYC Pak et al, Annals of Internal Medicine ). Fluoride treatment had no significant effect on any of the measured acoustic velocities. There were only small effects of fluoride on bone histomorphometry. Female Wistar rats.5 months old were divided into baseline, sham-operated (sham sham-treated with NaF.5 mg NaF/kg/day in drinking water, and ovariectomy (OVX OVX treated with NaF and with estrogen. The vertebral fluoride content at which femoral strength was maximum was between 1,100 and 1,500 ppm. LS BMD increased from a median.77 g/cm2 (range.69.99) at baseline.88 g/cm2 (0.75.13) (p.001) after 12 months. Moreover, fluoride is a cumulative element and Edmonton was fluoridated for less than 20 years when records of fracture hospitilization rates were checked. In all patients where the timing was known, the initial and subsequent fractures were preceded by, or associated with increased bone turnover as measured by plasma alkaline phosphatase (pAlP) (i.e., they were all "good responders.